Human paragonimosis in Colombia was assumed to be restricted to the sylvatic areas. However, in 2005, crabs infected with Paragonimus were found in Fuente Clara, an urban sector in Medellín.A study was designed to understand the ecoepidemiology of paragonimosis. Programs were initiated to educate the community in the suitable use of wetland ecosystems.Infection rates of Paragonimus in human and wild hosts was documented in the Fuente Clara sector. The presence of larvae and digenic adult worms was detected in mollusks (1,312), crabs (27) and mammals (4). Sputum diagnosis was performed on samples from 18 volunteer individuals. The following determinants of water quality were measured in the stream La Puerta: total fecal/coliform, pH, conductivity and dissolved oxygen were measured. Recreational workshops were conducted with children and teenagers for educational purposes.The percentage of infections found in hosts was as follows: snails, 0.07%; crabs, 55.5%; (wild) mammals, 25%; humans, 0%. During the workshops, children and teenagers identified the Paragonimus hosts and the risk factors for acquiring the disease. The water of the stream was found to be unsuitable for consumption and recreation (the most probable number of total coliforms/100 ml was in a scale of 104).Fuente Clara is the first urban locality in Colombia where a focus of Paragonimus was found. Exposure to and consumption of crabs may constitute a risk for human infection.