Several solid catalysts were evaluated as an alternative for 1,2,3,4‐tetrahydroisoquinoline synthesis by means of the Pictet‐Spengler reaction. The reaction catalysed by a mixed oxide (Mg and Al) led to the best yield and good regioselectivity; using an Al‐pillared bentonite led to good yields and total regioselectivity. The results revealed no direct relationship between catalyst acidity and yield.