Mexico is considered a mammal diversity hotspot, and most conservation efforts involving mammals focuson large and charismatic species. Herein, we provide an assessment of the conservation status of species that are oftenoverlooked in conservation programs, Mexican rodents of the families Geomyidae (pocket gophers) and Heteromyidae(pocket mice and kangaroo rats). Based on distributional maps and recent systematic studies, a taxonomic andbiogeographical distributional checklist was made. The conservation lists of the International Union for Conservationof Nature and the Mexican Secretaría de Medio Ambiente y Recursos Naturales were used to identify 8 geomyidspecies, and 8 species and 27 subspecies of heteromyids as endangered. Major threats to their conservation are changein land use, destruction of habitat and a lack of knowledge about their current distribution and population trends.