This paper reports on the position of Brazil andColombia against infrastructure integrationprocesses, understood as part of the process ofregionalization in the South American territory.The study begins placing each of the countrieswithin the regional system and the relationshipof this with its deployment within the internationalsystem. After this, we analyze theway Colombia has addressed infrastructuralintegration inside its foreign policy agendas, oriented towards the relations with its neighbors,realizing the lack of a strategic perspective by theState on the potential subregional which couldassume leadership within the South Americaninfrastructure integration.