We study the resonant photoionization of the Helium atom subject to ultrashort laser pulses by using a Feshbach formalism in the time domain. We solve the projected time-dependent Schrodinger equation in terms of a configuration interaction spectral method, with a total wave function expanded with configurations defined within bound-like () and scattering-like () halfspaces. The method allows for accurate descriptions of both the atomic structure (energy positions and widths) as well as for the resonant photodynamics using ultrashort laser pulses. Special attention is given to the temporal formation of Fano profiles in the one- and two-photon ionization cross sections.