Abstract One of the major problems in mature fields undergoing secondary recovery is the contamination with sulfate reducing bacterias (SRB) of the injection water system (fresh and/or production) and/or of the reservoir (natural or by drilling fluids, completion, stimulation, etc.), which causes formation damage and microbiological induced corrosion (MIC) in the injection-production system. The problems mentioned above are present in various fields of the state oil company, Ecopetrol S.A, in Colombia and the situation is becoming more critical, not only because the decrease in productivity (formation damage, failure of the subsurface equipment and facilities of the Injection-Production system, etc.), but mainly because the risk of human mortalities (maintenance jobs, nearby houses, etc.). In some producing wells, H2S concentrations have exceeded the lethal limits of 20 ppm and there are cases of producing wells with levels above 1000 ppm. Based on the above, a conceptual study was developed and an experimental protocol for the selection and evaluation of matrix stimulation treatments with biocides, focused on H2S and corrosion control in Producer Wells of Fields Undergoing Secondary Recovery as part of the comprehensive strategy to implement in the injection-reservoir-production system of the Cira - Infantas field in Colombia. This study included the following stages: State of the art to define main Bactericides-sporicidal.State of the art to define matrix stimulation treatments to H2S and corrosion control, removal of biomass (biofilm) and iron sulfide, etc. in producers wells.Deactivation of bactericides and sporicides with gases and minerals of the formation (H2S, Clay, etc.) and the environmental Impact.Alternatives Assessment Matrix.Formation damage by growth of sulfate-reducing bacteria.Experimental protocol and results of selection and evaluation of biocides and stimulation treatments. Finally, the main findings, conclusions and recommendations obtained in this study are shown.