Life-cycle cost (LCC) analysis entails consideration of building performance throughout the structures’ life. The impact and interaction of topology irregularities and construction quality (CQ) on LCC, however, are often ignored and require a more detailed evaluation. In this article, different levels and interaction of soft story (SS) and CQ are analytically modeled to quantify corresponding fragility curves and LCC (by considering hazard level, limit state cost, and probability of being in different damage states). The proposed method is illustrated with a three-, six-, and nine-story reinforced concrete building located in Vancouver (located in west coast of Canada).