More individuals are living with traumatic brain injury due to medical and technological advancements. Consequently, family researchers and clinicians will likely work with families facing this type of injury. It is important to examine how family members’ perceptions of challenges associated with brain injury influence their outcomes and whether families experience difficulties when members have differing perceptions. Results of hierarchical linear modeling analyses showed that survivors’ and caregivers’ satisfaction with life was negatively influenced by their own, but not the other’s, perceptions of survivor functioning. Survivors and caregivers with similar perceptions of survivor neurobehavioral functioning also reported greater satisfaction with life. Research and clinical implications are discussed.