Abstract magnified image New bis‐3,5‐diphenylpyrazoline derivatives have been synthesized according to Elway [1] (1999) and Sangwan's[2] (1992) methodology. Most of them were obtained in good yields, from the reaction between an alkyl linked bis‐chalcones and hydrazine in acetic acid. The activity of some bis‐pyrazolines was evaluated against Helicobacter pylori.