Abstract Malaria is a parasitic disease that affects an estimated 500 million people in the world. It kills two million people a year, more than any other disease, and is currently endemic in over 100 countries. Within the oil and gas industry, malaria is a major cause of sickness in high malaria risk countries and an significant cause of death from an occupational illness. Although the biology of, and defence mechanisms against, Malaria have been known for some time, fatalities amongst Oil & Gas personnel on assignment to Malarious areas still occur. This paper summarizes the key elements of a comprehensive strategy on Malaria Management to be released in May 2006 by the joint Health Committee of the International Association of Oil & Gas Producers (OGP) and the International Petroleum Industry Environmental Conservation Association (IPIECA). If a company is considering business opportunities in malarious settings, it is critical to consider development of an appropriate MMP for all phases of the business activity. OGP and IPIECA member companies support the managements systems approach, and that management system should include a suitable malaria management program based on a full assessment of the risks and measures to address such risks In addition to their own workforces, this program may cover a variety of contractors and suppliers. Overall, an integrated approach, using primary, secondary and tertiary prevention, is likely to have the greatest chance of success. This paper outlines a basic strategy for such a management system, called a Malaria Management Program (MMP), and is a summary of good practices which form the basis for a new publication from the OGP-IPIECA Health Committee ‘Guidelines for Managing Malaria in the Oil & Gas Industry’.