A search for the standard model Higgs boson decaying to W+W- in pp collisions at sqrt(s) = 7 TeV is reported. The data are collected at the LHC with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. The W+W- candidates are selected in events with two charged leptons and large missing transverse energy. No significant excess of events above the standard model background expectations is observed, and upper limits on the Higgs boson production relative to the standard model Higgs expectation are derived. The standard model Higgs boson is excluded in the mass range 129-270 GeV at 95% confidence level.