It is common in the oil industry to complete horizontal wells selectively. Even, this selection is performed naturally since reservoir heterogeneity may cause segmented well performance. Segmentation may be partially open to flux due to high skin factor or low permeability bands. They can be treated as a nonuniform skin distribution. A few models have been introduced to capture these special details. Existing interpretation methodologies use non-linear regression analysis and the TDS technique; but, there is an absence of equations for the conventional technique. In this study, the conventional methodology is developed for the analysis of pressure transient tests in horizontal wells with isolated zones so directional permeabilities and skin factors can be obtained. The developed expressions were tested successfully with several examples reported in the literature and compared to results from other sources.