The prevalence of chronic diseases has been increasing globally and in the region of the Americas. The World Health Organization states that the population older than 60 years has doubled in the last 30 years, and the cost of these diseases to health systems is of immense significance. Neurologic diseases, such as dementia and cerebrovascular disease, as well as chronic obstructive pulmonary disease, significantly deteriorate the quality of life of patients owing to an increase in symptoms that are often not treated. The management of chronic symptoms, which is the basis of palliative care, becomes a major approach to the patient, his or her family, and the system. This article seeks to show the importance of joint work between physicians and palliative care specialists to define the most appropriate management for these patients and optimize quality of life.