Introduction: Painful procedures are a major source of distress for children with chronic disease and procedural sedation is recommended for these patients. Children with inflammatory bowel disease undergo several endoscopies during the course of their illness and no data are currently available about the psychological impact of repeated sedations on patients and their families. The aim of the study was to evaluate the psychological impact of repeated deep sedations with propofol for colonoscopy on children with IBD and on their families in a gastroenterology unit assisted by a pediatric procedural sedation unit. Methods: A questionnaire was administered to parents and to 28 pediatric patients affected by IBD, who underwent a minimum of 4 endoscopies performed with deep sedation using propofol as a single sedative agent. The issues addressed in the questionnaire covered different items concerning attitudes versus sedation and recovery phase, preparation to endoscopy, endoscopy. Results: All families addressed answered the questionnaires. Distress related to sedation was reported by 3/28 (11%) patients, expressing fear of getting asleep. Only 4/28 (14%) reported some pain while undergoing procedure. Instead, the major complaints of children concerned the precolonoscopy phase and in particular the administration of intestinal washing solutions (18/28, 64%), fasting (12/28, 42%) and the waiting times (7/28, 25%). Twenty-two over 28 (79%) parents think that their children do not feel pain during procedure, with a strict correspondence between patients’ and parents’ perceptions toward sedation. Conclusion: Repeated deep sedation with propofol is well accepted by patients and parents and it is systematically requested for endoscopies.