The tomato is one of the most cultivated and consumed vegetables in the world.However, in Colombia, the yield of the tomato crop is suboptimal.Therefore, in this study, the effect of the number of clusters on tomato production was evaluated under greenhouse conditions in the municipality of Turmequé (Boyacá).A completely randomized design was used with three treatments corresponding to the number of clusters per tomato plant (8, 10 or 12) with 16 replicates.Production was determined by commercial grades and an economic analysis was made.The results indicated that there was a statistical difference among the qualities first, second, third and total, whereas extra and fourth did not differ significantly.In general, there was a linear increase of production in function of number of clusters/plant, except for the extra quality.The treatment of 12 clusters per plant generated the highest total yield and good response in other categories; also it had the highest costs of production, profitability, and net income.