ABSTRACT: Colombian environmental authorities are exploring new alternatives for improving the disposal of hospital waste generated in the Department of Boyacá (Colombia). To design this hospital waste management network we propose a biobjective obnoxious facility location problem (BOOFLP) that deals with the existing tradeoff between a low-cost operating network and the negative effect on the population living near the waste management facilities. To solve the BOOFLP we propose a hybrid approach that combines a multiobjective evolutionary algorithm (NSGA II) with a mixed-integer program. The algorithms are compared against the Noninferior Set Estimation (NISE) method and tested on data from Boyacá’s hospital waste management network and publicly available instances.