This article is based on dimensioning of autonomous photovoltaic systems in the residential sector of Colombia using HOMER software. The simulations were performed for each of the capitals of Colombia, which were grouped according to their levels of solar radiation, thus ensuring the distribution over the entire geographic area of the country. The system load was determined taking as a reference non-interconnected areas because they represent a large part of national territory. The selection of the devices comprising the system was performed using a methodology that takes into account certain criteria that improve the viability of implementing the system. Finally, comparative results are presented in technical and economic terms according to the radiation levels required to implement the system. The results serve as an approach to implement these systems in areas with similar characteristic.