A particular case of direct inequity conditions related to gender differences is the prevailing level of unequal income in urban centers in Latin America. The existence of this phenomenon within specific regional clusters is the core argument of this study. To support this claim, this paper establishes comparative considerations from gender income inequities in Latin American urban centers, in 1997 and 2006. To this feature of direct inequity based on gender differences, it is important to add other discriminate practices still alive, such as the fact that in some areas girls do not enter to study or prepare themselves, in fields more related with technology and productive innovation. Based on results from this study, Latin America as a region has shown improvements in income inequalities, but there is indisputable need for improvements. Countries such as Peru, Brazil and Bolivia appear with high standards of income differences based on gender discrimination.