Information systems (ISs) are the cornerstone of manufacturing companies. These rely on technical ISs that enable the integration between the infrastructures and the support of design and production management activities. For them, ‘strategic alignment’ is crucial for business performance. It exists when the ISs and business goals and activities are in concordance. In the literature, it is often approached from a top managerial point of view, whereas it had also to be managed at an operational level through integration into the upstream phases of the ISs design and development. To succeed in, we propose the Extended-Strategic Alignment Model and an exploitation process. They support the systematic study of the mutual influences between business, information technology and product design or manufacturing. The propositions are illustrated on the part monitoring module of the manufacturing workshop from a real small and medium enterprise.