To describe the ultrasonographic and MRI findings in a group of fetuses with confirmed congenital toxoplasmosis. Physicians working in the field of prenatal diagnosis in ten Latin America countries were contacted between 2006 and 2009; and asked to participate in the study by providing through the web clinical and imaging data on patients with a positive diagnosis of congenital toxoplasmosis. Intracranial findings suggestive of congenital toxoplasmosis were identified in eight patients at a mean gestational age of 30.4 weeks of gestation (range 24.4–34). Ventriculomegaly was severe in three patients and mild in four. Multiple echogenic nodular foci consistent with calcifications were found in seven patients and were located in the brain parenchyma (7), in the periventricular zone (3), or in the caudo-thalamic zone (3). In the remaining patient the ventricular dilatation and brain destruction was so severe that the brain was difficult to observe. Diffuse periventricular echogenicity or periventricular cysts were depicted in three patients and callosal dysgenesis in one. MRI confirmed US findings in two patients. Six children survived and suffer from neurodevelopmental delay (5), seizures (4), blindness (4), and choroidoretinitis (3). The association between ventriculomegaly and multiple echo-dense nodules affecting the periventricular tissue, the intermediate zone, the cortex, and the basal ganglia is characteristic of congenital toxoplasmosis. These findings are associated with a poor prognosis.