Today companies don’t have time and resources availability to stop their production to evaluate new layout and strategies, unless the results are guaranteed. Developing or redesigning products, gathering them in a product family and creating product platforms can be expensive tasks that represent a meaningful outlay for companies if they don’t have the adequate tools in order to facilitate the work. Thus, it is important to define the most appropriate manufacturing system as well as the performance of the chain value and the equipment layout in order to achieve an optimal production with the best quality and the shortest times and production costs. Therefore, computational tools, validated by working strategies and philosophies as Lean Manufacturing (LM) and Product Lifecycle Management (PLM) become necessary. After the evaluation of products, the value chain and the layout, these tools allow the construction of models and simulations as dynamic Value Stream Map (dynamic VSM), to analyze the actual process functioning or future process plans and PLM software, to estimate production flows, equipment and human labor requirements without stopping the normal production activities and providing competitive advantages to the company.