Research technology organisations or RTOs have attracted academic interest in the last decade due to their role as technology transfer agents and R&D collaborative leaders for firms and especially for small and medium enterprises (SMEs). Although their role within the diversity of specialised structures in generating R&D for industry in National Innovation Systems is recognised, there are scarce publications in relation to their strategies, performance or characteristic, as leaders of R&D collaboration with SMEs. The aim of this work is to identify the role, barriers and facilitators for RTOs performance as well as to develop a contingency relationship between industry environment, strategy, organisational structure and other factors for successful technology transfer from technology organisations to SMEs. This research is based on a field study conducted on 14 technology organisations based in the Valencia region, working with various industry sectors.