This study explored the relationship between the Burnout Syndrome and Work Engagement with demographic and labor variables among university academics of Zacatecas. Materials and methods: through a quantitative methodology, an observational analytical, cross-type study was designed by using a sample size of 98 women and 58 men. The instrument of Maslach's Burnout Inventory and the Utrecht Work Engagement Scale with 17 items were used. Results: 62,8% female and 37,2% male had, on average, an age of 44 years. Regarding the Burnout, a high level of exhaustion was observed, where 35,3% of participants had, at least, one dimension burned. A significant relationship (p_ 0,05) between sex, age, and gender with emotional exhaustion was found. The 99,4% of the participants had high levels the Work Engagement. Conclusion: Notwithstanding the constant academic changes, and the physical and psychological strain found among academics, they presented high levels of job engagement.