The experience achieved by the Water and Sewerage Systems Research Center (CIACUA) at Universidad de los Andes, in the application of the methodology that establish the optimal water head pressure at the entrance of a hydraulic sector in a drinking water distribution system, has allowed to obtain conclusions and results for the Colombian case. The methodology permits an efficient management of the resources and a suitable cost planning of capital and operation of the network. It also helps to reduce the commercial and technical water losses as it decreases the amount of burst pipes and raises their life time due to a less operational pressure. As well it identifies zones with high rates of technical losses to detect leaks and illegal connections, and spatial localization of users with consumption zero. All of these are done to develop renewal and rehabilitation strategies as well as long term investment in the networks. An essential part of the methodology is the calibration of the systems that returns a model that can be used as an operational tool. This article summarizes the differences between the results when the methodology is applied, comparing the calibrated models obtained and making recommendations for the different networks and future investigations. This paper was presented at the 8th Annual Water Distribution Systems Analysis Symposium which was held with the generous support of Awwa Research Foundation (AwwaRF).