Abstract Abstract Design guidelines were applied for the production of methyl acetate in a pervaporation membrane reactor. The limits of operation were determined. The shift in equilibrium is evaluated by a simple model involving simultaneously chemical equilibrium and transport across the membrane. This analysis establishes possibilities and limitations of a pervaporation membrane reactor. The performance of a continuous stirred tank reactor with a pervaporation membrane (PV-CSTR) is analyzed. To achieve conversions higher than 90%, conditions must satisfy D a > 150 and 0.01 < P e < 100. Increasing temperature has a negative effect on membrane reactor conversion. The effect of sweep is important at high-permeate pressures. Two design charts were created to illustrate dynamics between permeation rates, reaction rates, and selectivity with conversion. The three powerful tools proposed for the analysis of a pervaporation membrane reactor described the system in a systematic way. Keywords: Pervaporation membrane reactorDesign methodologyDesign chartsMethyl acetate Acknowledgment The authors thank to the Dirección de Investigaciones of the Universidad Nacional de Colombia, Sede Manizales, for financial support of this research.