Human Trafficking is a social phenomenon, a crime, a human rights violation and a persistent practice throughout human history. The following pages approach human trafficking from a specific context, both from a concrete regional perspective (migration flows from and to Central and North America) as well as to a labor oriented immigration regulatory scheme. Particularly, the guest worker programs in the United States and Canada. In order to demonstrate how human trafficking occurs not only within contexts of irregular migration or in which legal schemes are absent, but rather how certain migratory regulation programs are fertile ground for human trafficking. Demonstrating how some of the responses and measures being implemented to tackle with human trafficking are being challenged, and how innovative proposals are being developed both by scholars and civil society.