This study presents the results of DNA interaction of 52 methanol and 51 dichloromethane crude plant extracts with herring sperm DNA evaluated in terms of absorbance reduction of the peak, following the HPLC method described by Pezzuto and his colleagues. The 103 plant extracts belong to the Asteraceae, Euphorbiaceae, Melastomataceae, Rubiaceae, and Solanaceae families and were collected in the Regional Natural Park Ucumarí (RNPU; Colombia). The highest percentages of DNA interaction within the six plant families studied were shown by the methanol extracts of Schistocarpha sinforosi. Cuatrec. (68.30%) Aspilla quinquenervis. Blake (50.74%), and Verbesina nudipes. Blake (43.20%), all members of the Asteraceae family, followed by the methanol extract of Deprea glabra. (Standl.) A.T. Hunziker (41.01%), a species of the Solanaceae family. The dichloromethane plant extracts studied displayed, a low percentage of DNA interaction.