Objective-The mechanisms responsible for normal and abnormal parturition are poorly understood.Myometrial activation leading to regular uterine contractions is a key component of labor.Dysfunctional labor (arrest of dilatation and/or descent) is a leading indication for cesarean delivery.Compelling evidence suggests that most of these disorders are functional in nature, and not the result of cephalopelvic disproportion.The methodology and the datasets afforded by the post-genomic era provide novel opportunities to understand and target gene functions in these disorders.In 2012, the ENCODE Consortium elucidated the extraordinary abundance and functional complexity of long non-coding RNA genes in the human genome.The purpose of the study was to identify differentially expressed long non-coding RNA genes in human myometrium in women in spontaneous labor at term.Materials and Methods-Myometrium was obtained from women undergoing cesarean deliveries who were not in labor (n=19) and women in spontaneous labor at term (n=20).RNA was extracted and profiled using an Illumina ® microarray platform.The analysis of the protein coding genes from this study has been previously reported.Here, we have used computational