The solubility of 2,8,14,20-tetramethyl-4,6,10,12,16,18,22,24-octahidroxyresorci[4]arene, calix[4]resorcinarene, in water has been measured for temperatures ranging from (278.15 to 308.15) K. The experimental data were correlated with the van't Hoff equation, quadratic equation, and Apelblat equation. The thermodynamic functions of free energy and the enthalpy and entropy of solution were evaluated. The results showed that the main contributor to the standard free energy of solution is the enthalpy.