Introduction. Chronic leg ulcers are a burden for the health system and impact quality of life. Theinfections, the necrotic tissue and the difficult treatment affects the prognosis and healing time. Maggottherapy is presented as an acceptable alternative for the debridement and treatment of this pathology.Objective. The larval therapy was assessed on chronic leg ulcers with little necrotic tissue. Larvalexcretion and secretion (E/S) was characterized with respect to hemolymph (HL) enzymatic content.Materials and methods. Three patients with chronic leg ulcers and low necrotic tissue were treatedwith larval therapy and were assessed with the PUSH (pressure ulcer scale for healing) and WoundBed Score. E/S and HL content was evaluated by SDS PAGE and zymogram.Results. The clinical aspect of the wounds showed improvement, and the scores demonstrated anaverage decrease of 2.3 for the PUSH and an average increase of 2.7 for the Wound Bed Score.A wide diversity of enzymatic activity in the E/S was demontrated with major activity belonging to serineprotease family.Conclusions. Maggot therapy proved an effective treatment in cases with minimal tissue necrosis andcan be considered a viable treatment option.