Morphological modifications and cytochemical changes in the acid phosphatase on oxintic cells of the gastric mucosa of rats deprived of food for varying lengths of time were studied. With long fasting periods a lysosomal qualitative increase and mitochondrial morphological alteration are caused. This last fact would make an ATP decrease and an alteration in the ATPase actuation, so preventing the interchange of H+ for K+ and thus blocking intra-vesicular HCl formation.
