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A multiscale method for a robust detection of the default mode network

Acceso Cerrado
ID Minciencias: ART-0000305065-329
Ranking: ART-ART_D

Abstract:

The Default Mode Network (DMN) is a resting state network widely used for the analysis and diagnosis of mental disorders. It is normally detected in fMRI data, but for its detection in data corrupted by motion artefacts or low neuronal activity, the use of a robust analysis method is mandatory. In fMRI it has been shown that the signal-to-noise ratio (SNR) and the detection sensitivity of neuronal regions is increased with di erent smoothing kernels sizes. Here we propose to use a multiscale decomposition based of a linear scale-space representation for the detection of the DMN. Three main points are proposed in this methodology: rst, the use of fMRI data at di erent smoothing scale-spaces, second, detection of independent neuronal components of the DMN at each scale by using standard preprocessing methods and ICA decomposition at scale-level, and nally, a weighted contribution of each scale by the Goodness of Fit measurement. This method was applied to a group of control subjects and was compared with a standard preprocesing baseline. The detection of the DMN was improved at single subject level and at group level. Based on these results, we suggest to use this methodology to enhance the detection of the DMN in data perturbed with artefacts or applied to subjects with low neuronal activity. Furthermore, the multiscale method could be extended for the detection of other resting state neuronal networks.

Tópico:

Neural dynamics and brain function

Citaciones:

Citations: 2
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Información de la Fuente:

SCImago Journal & Country Rank
FuenteProceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Cuartil año de publicaciónNo disponible
Volumen8922
IssueNo disponible
Páginas892209 - 892209
pISSNNo disponible
ISSN0277-786X

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