This study recruited 90 traumatic brain injury (TBI) caregivers from Guadalajara, Mexico to examine influences of five domains of TBI impairment and related caregiver stress on five types of family needs. Canonical correlations suggested that greater social impairment in individuals with TBI and related caregiver stress were associated with higher informational, household and health needs in families. Meanwhile greater physical impairments in individuals with TBI and related caregiver stress were associated with higher household needs. Additionally, greater emotional impairments in individuals with TBI and related caregiver stress were associated with higher informational needs. Caregiver interventions targeting specific TBI impairments and related caregiver stress may meet family needs and thereby improve the quality of informal care for their family members with TBI.