Position paper on the results of Symplicity HTN-3 trial. Grupo de estudio de la hipertensión arterial resistenteAbstract Renal artery denervation has shown to be an effective treatment for resistant hypertension.Symplicity HTN 1 and 2 trials showed in small and uncontrolled groups, significant systolic blood pressure reductions down to 30 mm Hg.Symplicity HTN-3, a double blind, randomized, placebo controlled clinical trial shaded this initial enthusiasm.Surprisingly, their results showed that renal denervation has a similar effect to placebo.Pre-specified subgroup analysis showed that non-black race individuals, younger than 65 years and with normal renal