Our aim was to determine the influence of postnatal environment on cardiovascular (CV) remodeling in IUGR children. A cohort study in 5 years-old children including 80 IUGR (defined by birthweight < p10) matched by gender and gestational age at delivery (GAD) with 120 children with adequate fetal growth (AGA). Postnatal left ventricular sphericity index (LVSI) by echocardiography, carotid intima-media thickness (cIMT) and blood pressure were considered as CV end-points. Linear and robust regressions were fitted adjusted by matched variables in order to evaluate the effect of prenatal and postnatal variables on the CV end-points. LVSI was significantly lower, while cIMT and blood pressure were significantly increased in IUGR. Factors related to LVSI were IUGR (coefficient −0.404), pre-eclampsia (−0.099), cIMT (−0.089), child height (0.004) and breastfeeding (0.098). Otherwise,IUGR (0.020), paternal smoking (0.009), child age (0.004), child body mass index (0.002), low socio-economical status (0.013) increased the cIMT, while GAD (−0.002) and healthy fat ratio (−0.013) decreased it (figure). Adjusting by GAD, gender and child height centile, IUGR and child age increased systolic and diastolic blood pressure in a similar and significant magnitude (almost 5 and 1 mmHg, respectively). Supporting information can be found in the online version of this abstract Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.