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Treatment of Luteal Phase Defects in Assisted Reproduction

Acceso Cerrado
ID Minciencias: ART-0000875716-7
Ranking: ART-ART_A1

Abstract:

Abnormal luteal function is a common issue in assisted reproduction techniques associated with ovarian stimulation probably due to low levels of LH in the middle and in the late luteal phase. This defect seems to be associated with supraphysiological steroid levels at the end of follicular phase. The luteal phase insufficiency has not got a diagnostic test which has proven reliable in a clinical setting. Luteal phase after ovarian stimulation becomes shorter and insufficient, resulting in lower pregnancy rates. Luteal phase support with progesterone or hCG improves pregnancy outcomes and no differences are found among different routes of administration. However, hCG increases the risk of ovarian hyperstimulation syndrome. In relation to the length of luteal support, the day of starting it remains controversial and it does not seem necessary to continue once a pregnancy has been established. After GnRHa triggering ovulation, intensive luteal support or hCG bolus can overcome the defect in luteal phase, but more studies are needed to show the LH utility as support. Keywords: Assisted reproduction treatments, GnRH agonist triggering, hCG, LH, luteal phase support, progesterone.

Tópico:

Ovarian function and disorders

Citaciones:

Citations: 8
8

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Paperbuzz Score: 0
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Información de la Fuente:

SCImago Journal & Country Rank
FuenteCurrent Drug Targets
Cuartil año de publicaciónNo disponible
Volumen14
Issue8
Páginas832 - 842
pISSNNo disponible
ISSN1389-4501

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Artículo de revista