Pharmacokinetic Drug Interaction Studies Must Consider Pharmacological Heterogeneity, Use of Repeated Dosing, and Translation Into a Message Understandable to Practicing Clinicians
From the *University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY; and †Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; ‡Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina; and §IRCCS Centro Neurolesi "Bonino-Pulejo," Messina, Italy; and ∥Department of Statistics, Universidad Nacional de Colombia, Medellin, Colombia. Reprints: Jose de Leon, MD, UK Mental Health Research Center at Eastern State Hospital, 627 W 4th St, Lexington, KY 40508 (e-mail: [email protected]).
