This paper develops a Phenomenological Based Semiphysical Model (PBSM) of lumped parameters describing temperature and humidity dynamics in a spray drying chamber for natural products. We determined model parameters using both literature and own experimental data. The proposed model allows evaluating the controllability of the drying chamber, fundamental aspect when its apply Simultaneous Design of Process and Control System. This work is part of a research project in the development of solid formulations of natural dyes <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> . The aim is to move toward industrial-scale deployment of spray drying whole plant with the development of PBSM.