We describe the experience after two years working at the first exclusively Pediatric Hematopoietic Stem cell Facility in Bogota, Colombia. 26 hematopoietic stem cell transplants (HSCT) have been done in our program. 15 (57%) allogeneic and 11(43%) autologous HSCTs. Between allogeneic transplants all donors have been match related donors, 53% of allogeneic transplants because acute leukemia and 47% congenital or acquired bone marrow failure. Between autologous transplants 11 patients, 6 high risk neuroblastoma (55%), Relapsed Hodgkin disease (18%), AML (9%), PNET (9%) and Non Hodgkin lymphoma (9%). Primary results after two years are carefully described. Transplant related mortality is 11.5%, overall survival and event free survival are 50% and 50% respectively in a follow up of one year. We conclude that in a pediatric population is usual have more allogeneic transplants because of non malignant diseases, the primary results are comparable with those for long term experience centers given that the isolation rooms, pediatric facilities, Pediatric Intensive care in situ, and the well designed supportive care strategies.