Introduction: GERD in children may in 50% get complicated with esophagitis. The monitoring of the 24-hours intraesophageal pH (24h-pH) is the gold standard for the GERD diagnosis. Objective: To determine the possible relation between the histopathological findings of esophagitis and the 24h-pH on children with GERD. Materials and Methods: Transversal section descriptive observational study on children below 14 years old from the Hospital Universitario del Valle and the Hospital Infantil Club Noel in Cali, Colombia were studied. Data about identification (age and gender), symptoms (digestive and/or respiratory), weight, 24h-pH (parameters and relationship with symptoms) and the histopathology (esophagitis associated to GERD) was obtained from the clinical record. It was considered global malnutrition (MNT) when the deficit weight/age was > of 10% according to the NCHS. The results were expressed as an average and standard deviation, and for finding association (table of 2 × 2) OR and X2 were used, being p < 0.05 significant. Results: 49 children were included in the study, their ages oscillated between 4 months and 13 years old (5 years 3 months ± 3 years 8 months); 26 were boys; showing as predominant symptoms the respiratory 26.5% and digestive 8.16%; with global MNT of 34.6%. Out of the 49 24h-pH (reflux index 3.06 ± 3.12%; # of acid episodes 59.45 ± 57.92; # of acid episodes >5′ 0.98 ± 1.79 and duration of the longest episode 8.16 ± 12.72 minutes), 27 were abnormal by parameters and 18 were abnormal by association with symptoms. The histopathological findings reported esophagitis associated to GERD in 15 (31%) children. We did not find relation between the histopathological findings and the result of the 24h-pH (p < 0.05). Conclusion: Despite that we did not find relation between the histopathological findings and the result of the 24h-pH, it is still mandatory for children with GERD to include 24h-pH by parameters in their studies (RI, # acid episodes, # episodes >5′ and duration of the longst episode) and by association with symptoms (digestive and/or respiratory) and the high digestive endoscopy with biopsy taking (esophagitis due to GERD).