This work presents the study of the sea response on the vertical plane for a 40-m length overall coastal patrol vessel (CPV-40) of Colombia’s National Navy. The condition studied is at full load and at patrol and maximum speeds. First, we analyzed the response for regular waves with incidence angles of 90º, 120º, 150º, and 180º, obtaining the response for heave and pitch motions through the SCORES program that uses the method called “girdle theory”. From the response, it was verifiedthat the amplitudeof the response is proportional to the amplitudeof the incident wave. Thereafter, the calculation of the vertical acceleration was made for four ship positions: bow, stern, cabin, and bridge, with the greatest vertical accelerations on the bow. Finally,the study was conducted for irregular sea considering as measuring parameters the vertical acceleration on the bridge and the pitching angle for the patrol operation, from the NATO document, compliance was verified of the study parameters at RMS level. It was found that for this condition the vessel complies and, hence, the personnel will not be affected in the performance of their functions.