This article outlines the main characteristics of religious tolerance in New Granada in the period from 1849 to 1854. This work seeks to give an idea of how the concept of religious tolerance was understood during this period, as well as to discuss the particularities of the rhetoric of liberal and conservative political groups regarding the idea of tolerance in New Granada. Finally, I briefly analyze the expulsion of the Society of Jesuits around 1850 as a case of political and religious intolerance on the part of the Liberal state in the above-mentioned period. In conclusion, the legislation dealing with religious policies was contradictory during the years 1849 to 1854. This contradiction is clearly shown by the fact that during the governments of the so-called Mid-Century Liberal Revolution, who implicitly or explicitly leaned toward religious freedom, imposed measures like the expulsion of the Jesuits around 1850. That is, the legislation regarding religious policies became a failed attempt of modernity in the religious field.