Wear and tribological behavior of [HfN/VN]n multi-nanolayers deposited via magnetron sputtering has been exhaustively studied in this work. Enhancement of both hardness and elastic modulus up to 37 GPa and 351 GPa, respectively, was observed as bilayer periods in the coatings were decreased. The sample with a bilayer period (Λ) of 15 nm and bilayer number n = 80, showed the lowest friction coefficient (∼0.15) and the highest critical load (72 N), corresponding to 2.2 and 1.38 times better than those values for the coating deposited with n = 1, respectively. Taking into account the latest results of tungsten carbide (WC) inserts were used as substrates to improve the mechanical and tribological properties of [HfN/VN]n coatings as a function of increased interface number and to manage higher efficiency of these coatings in different industrial applications, like machining and extrusion. Their physical, mechanical, and tribological characteristics were investigated, including cutting tests with AISI 1020 steel (workpiece) to assess wear as a function of the bilayer number and bilayer period. A comparison of the tribological properties revealed a decrease of flank wear (approximately 24%) for WC inserts coated with [HfN/VN]80 (Λ =15 nm), when compared to uncoated tungsten carbide inserts. These results demonstrate the possibility of using [HfN/VN] multilayers as new coatings for tool machining with excellent industrial performance.