Introduccion: la tuberculosis (TB) pulmonar es un problema creciente de salud mundial y la resistencia a los antibioticos un elemento de preocupacion. Caso clinico : paciente de 19 anos, quien ingreso al servicio de urgencias por presentar hemoptisis. Antecedente de TB con tratamiento irregular. Se documento resistencia a varios medicamentos. Se consideraron las diferentes estrategias de tratamiento disponible. Debido al elevado riesgo epidemiologico y la historia de pobre adherencia al tratamiento, se realizo manejo intrahospitalario con respuesta satisfactoria. Conclusiones : la tuberculosis multirresistente (MDR-TB) representa un riesgo para la comunidad, teniendo en cuenta la via de transmision de la entidad. Rev.cienc.biomed. 2013;4(1):159-164 PALABRAS CLAVES Tuberculosis pulmonar; Tuberculosis resistente a multiples medicamentos; Antituberculosos. SUMMARY Introduction: tuberculosis is an increasing problem of global health and the microbial drug resistance a generating element of worry. Clinical case: 19 year-old patient, who admitted to the emergency room for presenting hemoptysis and who had history of pulmonary tuberculosis with irregular treatment. Multidrug-resistant tuberculosis was documented and different strategies of available medical treatment were considered. Due to the increased epidemiological risk and the history of poor adherence to the treatment, an in-hospital treatment was carried out with a satisfactory response. Conclusion: multidrug-resistant tuberculosis is a social risk, keeping the route of transmission of the disease. Rev.cienc.biomed. 2013;4(1):159-164 KEYWORDS Tuberculosis; Multidrug-resistant uberculosis; Antitubercular Agents.