<p>Background. An exponential law for chaotic cardiac dynamics,<br />found previously, allows the quantification of the differences<br />between normal cardiac dynamics and those with acute<br />diseases, as well as the cardiac dynamics of the evolution<br />between these states.</p><p><br />Objective. To confirm the clinical applicability of the developed<br />methodology through the mathematical law for cardiac<br />dynamics in dynamics with arrhythmias.</p><p><br />Materials and methods. 60 Holter electrocardiograms were<br />analyzed, 10 corresponded to normal subjects, and 50 to subjects with different arrhythmias. For each Holter, an attractor was performed, and its fractal dimension and spatial occupancy were measured. A mathematical evaluation was applied in order to differentiate normal dynamics from pathological ones. Sensitivity, specificity and the Kappa coefficient were calculated.</p><p><br />Results. The mathematical evaluation differentiated occupation spaces, normal dynamics, acute illness dynamics, and evolution between these states. The sensitivity and specificity values were 100%, and the Kappa coefficient was 1.</p><p>Conclusions. The clinical applicability of the methodology<br />for cases with arrhythmia was shown. It is also applicable for<br />the detection of changes in dynamics that are not classified<br />clinically as pathological.</p>