Here we show that the Weak Basis Transformation is an appropriate mathematical tool that can be used to find texture zeros in the quark mass matrix sector of the Standard Model. So, starting with the most general quark mass matrices and taking physical data into consideration, it is possible to obtain more than three texture zeros by any Weak Basis transformation. The general quark mass matrices considered, were obtained through a special weak basis transformation wherein the up-quark mass matrix (down-quark mass matrix ) has been taken to be diagonal and the down-quark mass matrix (up-quark mass matrix), in general form, includes the Cabibbo-Kobayashi-Maskawa matrix.