This work is based on a brief theoretical foundation that supports a methodological structure aimed at the calculations of climate change, the study of climate variability in the territory of the basins of the Zulia and Pamplonita rivers in Norte de Santander and the initial identification of potential measures of adaptation to climate change and climate variability..In its development, the climate change trends and the most likely alterations of the climate variability phenomena associated with the ENSO cycle for the period 1981-2010 in the basins of the object of study were identified and spatialized. The results obtained show that the average temperature has changed between 0.1 and 0.4°C per decade in the basins, precipitation has increased from 0 to 250 mm/decade and the ENSO cycles generate alterations in the climate variability of the basins on a differentiated manner on a seasonal and year-on-year level, especially in the Dec-Jan-Feb, Jun-Jul-Aug and Sep-Oct-Nov quarters.