This work had as objective to study the appropriate in captivity conditions for the handling of Ranitomeya bombetes in order to get a successful reproduction at the Cali Zoo. Many aspects were evaluated such as: different types of diets in larvae, the reproductive time, size and fertility of the clutchs, preference of oviposition place and ration sexes. Four different diets for the feeding of larvae were evaluated. The used diets were: meat-eating, herbivorous, TetraMin-ProCare® and meat-eating + TetraMin-ProCare® (50% each one). The diet analysis was only made until stage 30 because some larvae died. The diet with TetraMin-ProCare® was the most efficient because the larvae grew very quickly. In total, 53 eggs in 43 clutchs were collected. These 43, 33 were from 1 egg and the rest were from 2 eggs. The fertility was variable according to the proportion of sexes in each terrarium; of all eggs 35 were fertile. The mortality of embryos and larvae was of 10 and 8 respectively. The preference of clutch place was greater on the land substrate of cape as well as the fertility of the eggs that were clutched on this substrate. Furthermore, the description of the progressive changes of the clutch was carried out, emphasizing in the time of duration of the different embryonic and larval stages following the parameters morphologic from Gosner (1960). One became the photographic recording of some of the embryonic (6, 9, 10, 12, 14, 17, 18, 19, 20, 21, 23, 24 and 25) and larval (27, 28, 29, 34, 36, 38, 40, 41 and 42) stages besides the ventral and dorsal registry of the post-metamorphosis. Different sex proportions were evaluated in 8 terrariums. The proportion with a greater number of clutchs was of2♂:3♀. It was managed to successful reproduce the species under conditions of laboratory. A total of 4 frogs culminated all the metamorphosis and continued their growth.