The present study aims analyze and compare structural features in order to establish a model about the decline in HIV/AIDS infection (greater than or equal to 25 %) in twenty-two countries between 2001 and 2011.Retrospective cohort focused on social determinants of health perspective. The methodology was mainly documentary (epidemic behavior) and quantitative (simple linear regression model for economic and health variables).The major indicators that influence the decrease in the prevalence of HIV are: GDP per capita, health expenditure per capita and the Gini indexStructural determinants, as well as inequities, may or not influence the decrease in prevalence of HIV. This hypothesis could be applied to other public health issues.