This paper evaluates the effect of six water treatment combinations for the treatment of turbid surface water on four types of emitters by looking at clogging potential and distribution uniformity. The pilot plants use different combinations of upflow gravel filtration, disc filters, and slow sand filtration, fed with natural water from the Cauca River (Cali, Colombia). The outflow of these systems was used to feed four different types of emitters. The paper analyzes the removal of physicochemical parameters that affect emitter clogging and the distribution uniformity of the lower quarter (DUlq). All treatment schemes reduced clogging potential, with the best performance being obtained with upflow gravel filtration followed by slow sand filtration and upflow gravel filters in series. The effect on DUlq differed for the four types of emitters. The longest irrigation time was obtained for the pressure compensated emitter and for the Lyn emitter with 600 h of continuous operation until the DUlq was below 80%.